Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies

<div>MEP-induced apoptosis is associated with the activation of the ER stress pathway. (a) IPA was used to classify the proteins on the basis of disease and functional relation to altered proteins. (b) Top canonical pathways significantly altered upon MEP treatment. (c) Western blot validation of GRP78, ER stress proteins, and caspase 3 in a time-dependent study on MEP-treated (20 μg/mL) PC3 cells. Equal loading was confirmed by reprobing with GAPDH.</div>

Oxidative Medicine and Cellular Longevity

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Figure 6

Figure 6: Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies

Figure 6 | Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies 