Methane Alleviates Acetaminophen-Induced Liver Injury by Inhibiting Inflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis through the Nrf2/HO-1/NQO1 Signaling Pathway

Figure 6

MRS inhibited APAP-induced cellular oxidative stress. (a) Cell viability after treatment with APAP at doses of 5 mM, 10 mM, 15 mM, and 20 mM for 12 h, 24 h, and 36 h exposure, respectively; (b) GSH level in L-02 cells after treatment with 10 mM APAP concentration for 24 h; (c) immunofluorescence of ROS expression and (b) relative fluorescence intensity in the L-02 cells (^A as compared to the NM group, ^B as compared to the MRM group, ^C as compared to the APAP+NM group, and ^D as compared to the APAP+MRM group).

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