[Retracted] High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells

<div>High glucose enhanced bupivacaine-induced MCU expression elevation. Con: untreated cells; HG: cells treated with 25 mM glucose for 2 days; Bup: cells treated with 1.0 mM bupivacaine for 6 h; HG+Bup: cells cultured with 25 mM glucose for 2 days and treated with 1.0 mM bupivacaine for 6 h. (a) MCU mRNA was measured with qRT-PCR in cells treated with 1.0 mM bupivacaine for different times (3, 6, or 12 h). (b) MCU mRNA was measured with qRT-PCR in cells treated with 25 mM glucose for different times (1, 2, or 4 days). (c) MCU protein expression was measured with western blotting in cells cultured with 25 mM glucose for 2 days and treated with 1.0 mM bupivacaine for 6 h. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: [Retracted] High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells 