[Retracted] High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells

<div>Ru360 or the knockdown of MCU could attenuate bupivacaine-induced mitochondrial oxidative damage and apoptosis in SH-SY5Y cell incubation with high glucose. NC: cells transfected with silencer negative control siRNA; siMCU: cells transfected with MCU siRNA; Ru360: cells pretreated with 10 <i>μ</i>Μ Ru360 for 30 min; HG+Bup: cells cultured with 25 mM glucose for 2 days and treated with 1.0 mM bupivacaine for 6 h. (a) Mitochondrial damage was measured with JC-1. (b) Apoptotic cells (early apoptotic cells at the lower right quadrant for Annexin V-FITC-positive and PI-negative) were measured with flow cytometry. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: [Retracted] High Glucose Enhances Bupivacaine-Induced Neurotoxicity via MCU-Mediated Oxidative Stress in SH-SY5Y Cells 