Neutrophil Elastase Inhibitors Suppress Oxidative Stress in Lung during Liver Transplantation

Figure 5

Schematic representation of the effect of neutrophil elastase inhibitors suppressing oxidative stress in alveolar epithelial cells during liver transplantation. Liver transplantation injury induces neutrophil infiltration in alveoli and neutrophil degranulation and neutrophil elastase release which lead to pulmonary edema and dysfunction. Exogenous (sivelestat) and endogenous (SERPINB1) neutrophil elastase inhibitors activate antioxidant enzymes and attenuate lung damage by way of antioxidative stress.