Research Article

Resumption of Autophagy by Ubisol-Q10 in Presenilin-1 Mutated Fibroblasts and Transgenic AD Mice: Implications for Inhibition of Senescence and Neuroprotection

Figure 5

Immunohistochemical staining of the cerebral cortex from double transgenic mice probing for beclin-1 and JNK1. Oral supplementation of Ubisol-Q10 results in the upregulation of beclin-1 and JNK1 in transgenic mice similar to wild-type mice as indicated by the increased immunoactivity in the Ubisol-Q10-treated AD group compared to the untreated and PTS-treated groups. Micrographs were taken at 100x. .