The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα

Figure 1

Zileuton ameliorates cardiac hypertrophy and improves cardiac function in response to pressure overload in vivo. Mice were administered zileuton orally (100 mg/kg/d) from 1 week until 8 weeks after AB surgery. (a) Heart weight/body weight (HW/BW), heart weight/tibia length (HW/TL), lung weight/body weight (LW/BW), and lung weight/tibia length ratios in mice (). (b, c) HE staining () and quantification results in mice ( cells). (d) Transcription levels of hypertrophic markers (). (e) Echocardiography in mice (). (f) Hemodynamic measurements in mice (). vs. the vehicle-sham group; ^# vs. the vehicle-AB group. ZI: zileuton.

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