The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα

Figure 2

Zileuton relieves inflammation and oxidative stress in vivo. Mice were administered zileuton orally (100 mg/kg/d) from 1 week until 8 weeks after AB surgery. (a, b) Immunohistochemical staining and quantification results in mouse hearts (). (c) Transcription levels of inflammation markers (). (d) Immunohistochemical staining of 4-HNE (). (e, f) Protein expression levels of SOD2, NADPH P67, and gp91 (). (g) Activities of SOD, Gpx, and NADPH oxidase (). vs. the vehicle-sham group; ^# vs. the vehicle-AB group.

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