The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα

Figure 3

Zileuton reduces cardiomyocyte hypertrophy in response to PE. H9c2 cells were treated with PE (50 μM) and different concentrations of zileuton (1, 10, 50, and 100 μM) for 24 h. (a) Cell viability (). (b) Transcription levels of hypertrophic markers in H9c2 cells (). (c, d) α-Actinin staining () and quantification of cells. vs. the control group; ^# vs. the PE group.

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