The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα

Figure 4

Zileuton inhibits oxidative stress in cardiomyocytes. H9c2 cells were treated with PE (50 μM) and zileuton (100 μM) for 24 h. (a, b) ROS levels in H9c2 cells (). (c, d) Protein expression levels of SOD2, NADPH P67, and gp91 (). (e) Activities of SOD, Gpx, and NADPH oxidase (). vs. the PBS group; ^# vs. the PE group.

(a)

(b)

(c)

(d)

(e)