The 5-Lipoxygenase Inhibitor Zileuton Protects Pressure Overload-Induced Cardiac Remodeling via Activating PPARα

Figure 8

PPARα knockdown blunts zileuton’s antihypertrophic effect in vivo. Mice were subjected to AAV9-shPPARα injection. Two weeks after injection, the mice were subjected to AB surgery. One week after AB, the mice were treated with zileuton (100 mg/kg/d) for 7 weeks. (a) PPARα levels in the heart 10 weeks after AAV9-shPPARα injection (). (b) HW/BW, HW/TL, LW/BW and LW/TL ratios in mice (). (c, d) HE staining () and quantification results in mice ( cells). vs. the vehicle-sham group; ^# vs. the vehicle-AB group.

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