Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway

<div>Effects of resveratrol and/or H<sub>2</sub>O<sub>2</sub> on the expression of SOD-1, CAT, GSX-1, and HO-1 in IPEC-J2 cells. IPEC-J2 cells were pretreated with the indicated concentrations of RSV for 6 hours and then cocultured with 500 <i>μ</i>M H<sub>2</sub>O<sub>2</sub> for 4 hours. The expression of SOD-1 (a), CAT (b), GSX-1 (c), and HO-1 (d) was detected by qRT-PCR. Data are shown as ratios of abundance of target gene transcripts in the treated cells to those in the control cells after normalization to <i>β</i>-actin. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway 