Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway

Figure 2

GE protected against DOX-induced oxidative damage in vivo. (a) The mRNA expressions of several antioxidant enzymes (). (b) Activity of superoxide dismutase (SOD) (). (c) Levels of glutathione (GSH) (). (d) Activity of glutathione peroxidase (Gpx) (). (e–g) Levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE)-protein adducts, and 3-nitrotyrosine (3-NT) (). (h) Western blot and quantitative results in the indicated groups (). Values represent the . versus saline, versus DOX.

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