Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax

Figure 3

ICA inhibited oxidative stress in AGE-induced PC12 cells. (a) PC12 cells were exposed to AGEs and treated with ICA (5, 10, and 20 μM) for 48 h. Detection of intracellular and mitochondrial ROS using DCFH-DA and MitoSOX. Scale  μm. (b and c) PC12 cells were treated as in (a), and the intracellular level of SOD and MDA were detected. Data were presented as from independent experiments performed in triplicate. relative to the control group; , , and relative to the model group.

(a)

(b)

(c)