Role of HIF-1α-miR30a-Snai1 Axis in Neonatal Hyperoxic Lung Injury

Figure 7

Overall schematic. Hyperoxia increases SNAI1 expression in vitro, but females show decreased expression in vivo. miR-30a decreases Snai1 expression, and females show higher expression. HIF-1α increases both the miR-30a and Snai1 expressions, but HIF-1α-mediated miR-30a expression in females keeps the Snai1 expression in check upon exposure to hyperoxia.