Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease

Figure 1

Modified-HLJDD attenuates learning and memory impairment in the Aβ_1-42 oligomer-induced AD mouse model. (a–e) MWM tests were conducted after treatment with HLJDD, modified-HLJDD-L, modified-HLJDD-H, or donepezil. (a) The escape latency during a five-day training course. (b) In the probe tests, mice were analyzed for the escape latency; (c) the time spent in the target zone; (d) target crossing. (e) Representative path tracings in each quadrant during the probe trial. (f, g) T-maze/Y-maze results after HLJDD, modified-HLJDD-L, modified-HLJDD-H, or donepezil treatment in the AD model are presented as time spent in the novel arm. per group. Results are expressed as the . , vs. control group; ^##, ^# vs. model group; and ^& vs. HLJDD group. Statistical significance was determined by one-way ANOVA and Bonferroni tests as post hoc comparisons.

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