Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease

Figure 2

Identification of significant metabolites between HLJDD and modified-HLJDD extract solutions through UPLC-Q-TOF/MS. (a–d) The TCI of HLJDD and modified-HLJDD solutions under positive and negative ion modes. (e, f) Loading plot of PLS-DA and S-plot of OPLS-DA for HLJDD and modified-HLJDD. (g) The volcano plot showing all the significantly changed metabolites between HLJDD and modified-HLJDD solutions. (h) Pathway analysis for HLJDD and modified-HLJDD shown as a bubble plot. All assays were performed in triplicate.

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