Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease

Figure 3

Modified-HLJDD ameliorates glutamatergic synaptic transmission in the hippocampus in an AD mouse model. (a) Effect of HLJDD and modified-HLJDD on glutamatergic receptor expression determined by Western blotting. (b) Effect of HLJDD and modified-HLJDD on synaptic protein expression determined by Western blotting. (c) Immunofluorescent staining of NeuN and synapsin in the hippocampus. Scale bar, 100 μm. (d) Immunofluorescent staining of NeuN and Iba1 in the hippocampus. Scale bar, 100 μm. (e) Immunohistochemical staining of GFAP in the hippocampal CA1. Scale bar, 50 μm. per group. Western blotting results are from three of the nine mice in each group and are expressed as the of three experiments. , vs. control group; ^##, ^# vs. model group; and ^& vs. HLJDD group. Statistical significance was determined by one-way ANOVA and Bonferroni tests as post hoc comparisons.

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