Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease

Table 1

The proposed identity of main significantly increased metabolites in modified-HLJDD solution as compared with HLJDD solution ( and ).

No.	Rt (sec)		Scan mode	Proposed identity	Fold change
1	283.866	265.04975	ESI-	Uridine	8.98
2	335.147	145.01406	ESI-	Alpha-ketoglutarate	8.40
3	401.3015	274.10344	ESI-	Ribothymidine	7.26
4	447.433	229.03427	ESI-	Gallic acid	7.11
5	252.0905	736.18676	ESI+	Salvianolic acid L	5.86
6	429.9505	739.13038	ESI-	Salvianolic acid L	2.21
7	329.3	330.05854	ESI+	Cyclic AMP	5.09
8	240.281	328.04339	ESI-	Cyclic AMP	2.33
9	332.147	274.09177	ESI+	5-Deoxyadenosine	4.26
10	361.654	250.09206	ESI-	5-Deoxyadenosine	2.68
11	349.5	145.0617	ESI-	L-glutamine	4.89
12	349.445	147.07597	ESI+	L-glutamine	4.16
13	179.804	359.07497	ESI-	Rosmarinic acid	4.49
14	145.342	134.04704	ESI-	Adenine	3.59
15	144.513	136.06145	ESI+	Adenine	2.43
16	170.723	130.08876	ESI-	L-isoleucine	3.58
17	271.469	128.03637	ESI-	L-pyroglutamic acid	2.78
18	369.372	259.09214	ESI+	L-pyroglutamic acid	2.65
19	147.5605	279.03784	ESI-	Thymidine	2.41
20	370.018	250.092	ESI+	N-Acetyl-L-glutamate	2.21
21	355.314	188.05576	ESI-	N-Acetyl-L-glutamate	1.91
22	218.562	242.07682	ESI-	Cytidine	2.17
23	218.9115	244.0919	ESI+	Cytidine	1.64
24	369.475	268.10212	ESI+	Adenosine	2.12
25	330.727	236.07927	ESI+	N-Acetyl-L-aspartic acid	2.05
26	360.825	174.04019	ESI-	N-Acetyl-L-aspartic acid	1.39
27	316.1155	289.07948	ESI+	5-Methylcytosine	2.03
28	190.296	439.09881	ESI-	Gardenoside	2.00
29	293.1405	306.04803	ESI+	Cytidine 2,3-cyclic phosphate	1.94
30	250.9335	104.10697	ESI+	Choline	1.37
31	368.308	146.04593	ESI-	L-glutamate	1.53
32	368.0045	148.05971	ESI+	L-glutamate	1.35
33	251.085	130.08726	ESI-	L-leucine	1.50
34	288.0925	158.09171	ESI+	L-citrulline	1.49
35	101.406	168.06609	ESI-	Pyridoxine	1.39
36	352.4745	131.04657	ESI-	L-asparagine	1.33
37	352.261	133.06052	ESI+	L-asparagine	1.28
38	407.805	362.04978	ESI-	Guanosine 5-monophosphate (GMP)	1.19
39	232.449	164.07138	ESI-	L-phenylalanine	1.19

and .