Fenofibrate Improved Interstitial Fibrosis of Renal Allograft through Inhibited Epithelial-Mesenchymal Transition Induced by Oxidative Stress

Figure 7

Model. Fenofibrate improved interstitial fibrosis of the renal allograft through inhibiting EMT induced by oxidative stress. Fenofibrate increased the expression and activity of PPARα and suppressed EMT induced by oxidative stress (imaginary line showed other mechanisms, such as the fatty acid oxidation pathway), thereby reducing collagen fiber deposition and improving pathological injury of the renal allograft. Fenofibrate effectively delays the progress of IF/TA.