Resveratrol Inhibits MMP3 and MMP9 Expression and Secretion by Suppressing TLR4/NF-κB/STAT3 Activation in Ox-LDL-Treated HUVECs

Figure 6

Resveratrol reduces plasma MMP3 and MMP9 levels and decreases TLR4 expression in high-fat chow-fed mice. 36-week-old male mice were sacrificed after being fed high-fat chow for 12 weeks (/group). Plasma MMP3 and MMP9 levels were analyzed by an ELISA kit. Sirius staining was used to detect collagen in aortic sections. Immunohistochemistry was used to analyze vascular TLR4 expression. (a) Resveratrol decreased plasma MMP9 levels but had no effect on MMP3 levels in high-fat chow-fed mice (). (b) Resveratrol exerted a protective effect on vascular elastic structure in high-fat chow-fed mice (). (c) Resveratrol reduced vascular TLR4 expression in high-fat chow-fed mice (). The images are representative of the results from each group.

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