Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling

<div>SAC inhibited antioxidant enzymes (catalase, SOD, and GPx) (a) and detoxification capacities via the Nrf2/Keap1 signaling pathway (b) in APAP-induced acute liver injury in mice. Total protein was extracted from liver tissues, and the protein levels of catalase, SOD, GPx, HO-1, Nrf2, Keap1, NQO1, GCLC, and GCLM were determined by Western blot analysis. <i>β</i>-Actin served as a loading control. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling 

Figure 5 | Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling 