Astragaloside IV Attenuates Myocardial Ischemia-Reperfusion Injury from Oxidative Stress by Regulating Succinate, Lysophospholipid Metabolism, and ROS Scavenging System

Table 2

Differential lipid species contributed to group classification.

No.	Lipid	Lipid ion	Model vs. control			Astragaloside IV vs. model
			VIP value	value	log2(FC)	VIP value	value	log2(FC)
1	DG (18 : 1/22 : 4)	DG (18 : 1/22 : 4) +NH4	2.2076	0.001	1.6410	1.4538	0.040	-0.6451
2	CL (18 : 2/18 : 2/20 : 3/18 : 2)	CL (18 : 2/18 : 2/20 : 3/18 : 2)-H	2.5225	0.001	0.4739	1.4087	0.035	-0.2150
3	DG (22 : 6/22 : 6)	DG (22 : 6/22 : 6) +NH4	1.2593	0.008	-1.2863	1.4958	0.008	1.2987
4	FA (24 : 5)	FA (24 : 5)-H	1.8095	0.004	0.6340	1.5863	0.016	-0.4651
5	LPC (15 : 0)	LPC (15 : 0) +H	1.4051	0.023	0.5568	1.7333	0.013	-0.5419
6	LPC (16 : 0)	LPC (16 : 0) +H	1.4575	0.017	0.4393	1.8399	0.008	-0.4683
		LPC (16 : 0) +HCOO	1.8306	0.003	0.4709	1.4347	0.031	-0.2877
7	LPC (16 : 1p)	LPC (16 : 1p) +H	1.6036	0.008	0.5349	1.8856	0.006	-0.5417
8	LPC (17 : 0)	LPC (17 : 0) +H	1.8525	0.007	-0.5395	1.4751	0.016	0.4943
		LPC (17 : 0) +HCOO	2.0689	0.001	0.6604	1.5609	0.018	-0.3770
9	LPC (18 : 0)	LPC (18 : 0) +H	1.5194	0.013	0.4179	1.5409	0.029	-0.3576
10	LPC (18 : 1)	LPC (18 : 1) +H	1.3712	0.026	0.7205	1.8124	0.009	-0.7992
		LPC (18 : 1) +HCOO	2.0410	0.001	0.6449	1.5586	0.018	-0.4051
11	LPC (18 : 1p)	LPC(18 : 1p) +H	1.6013	0.008	0.6067	1.6208	0.021	-0.4767
12	LPC (20 : 1)	LPC (20 : 1) +HCOO	1.5674	0.014	0.4916	1.7422	0.007	-0.5742
13	LPC (20 : 3)	LPC (20 : 3) +H	1.5281	0.012	0.7497	1.7114	0.014	-0.5899
14	LPC (20 : 4)	LPC (20 : 4) +H	1.7039	0.004	0.6532	1.6392	0.019	-0.4448
		LPC (20 : 4) +HCOO	1.8538	0.003	0.6563	1.5171	0.022	-0.3879
15	LPC (22 : 4)	LPC (22 : 4) +H	1.7633	0.003	0.7929	2.0677	0.002	-0.7530
16	LPC (22 : 6)	LPC (22 : 6) +H	1.7244	0.004	0.6828	1.4231	0.045	-0.3728
		LPC (22 : 6) +HCOO	1.9491	0.002	0.7185	1.3837	0.038	-0.3549
17	LPE (17 : 0)	LPE (17 : 0) +H	1.3783	0.026	0.3498	1.7758	0.010	-0.5035
18	LPG (16 : 0)	LPG (16 : 0)-H	1.5975	0.012	1.1349	1.7168	0.008	-1.0794
19	LPG (18 : 1)	LPG (18 : 1)-H	1.3321	0.041	0.8443	1.7138	0.008	-0.9971
20	LPI (18 : 1)	LPI (18 : 1)-H	1.3081	0.045	1.0946	1.3901	0.037	-1.0277
21	LPI (18 : 2)	LPI (18 : 2)-H	1.4379	0.026	1.2306	1.5986	0.015	-1.2328
22	LPI (20 : 4)	LPI (20 : 4)-H	1.4179	0.029	1.0758	1.3296	0.047	-0.8204
23	MG (22 : 6)	MG (22 : 6) +H	1.3515	0.029	0.4772	1.6409	0.019	-0.6263
24	PC (16 : 2/18 : 2)	PC (16 : 2/18 : 2) +HCOO	1.0640	0.042	-1.0172	1.0495	0.043	0.7557
25	PC (17 : 0/18 : 2)	PC (17 : 0/18 : 2) +HCOO	1.4689	0.023	0.7415	2.0816	0.001	-1.0504
26	PC (36 : 5)	PC (36 : 5) +H	2.0056	0.001	1.8005	2.1950	0.001	-1.2854
27	PC (38 : 4)	PC (38 : 4) +H	1.3104	0.035	0.4454	1.7385	0.012	-0.5253
28	PC (41 : 4)	PC (41 : 4) +H	2.2853	0.001	1.6044	1.9778	0.004	-0.8453
29	PE (16 : 0/18 : 1)	PE (16 : 0/18 : 1)-H	1.7538	0.005	0.4561	1.7541	0.007	-0.4875
30	PE (18 : 0/20 : 5)	PE (18 : 0/20 : 5)-H	1.2958	0.048	1.0505	1.6508	0.012	-1.3285
31	PE (39 : 5)	PE (39 : 5) +H	1.9500	0.001	1.7287	1.5870	0.024	-0.9653
32	PE (19 : 0e)	PE (19 : 0e) +H	1.4636	0.017	0.4501	1.7815	0.010	-0.4539
33	PG (17 : 0/18 : 1)	PG (17 : 0/18 : 1)-H	1.3876	0.033	0.1410	2.0119	0.001	-0.2670
34	PS (37 : 3)	PS (37 : 3)-H	2.6293	0.001	3.0100	1.3271	0.048	-0.4890
35	PS (40 : 6)	PS (40 : 6) +H	1.3239	0.008	-0.5606	1.1997	0.008	0.5361
36	SM (d22 : 1/20 : 1)	SM (d22 : 1/20 : 1) +HCOO	2.6812	0.001	0.8807	1.5137	0.022	-0.2800
37	SM (d39 : 1)	SM (d39 : 1) +HCOO	1.8395	0.003	0.4619	1.4322	0.031	-0.3028
38	SM (d42 : 1)	SM (d42 : 1) +H	1.6231	0.007	0.5924	1.3941	0.050	-0.4197
39	SM (d22 : 0/18 : 1)	SM (d22 : 0/18 : 1) +HCOO	2.7354	0.001	0.6439	2.1077	0.001	-0.3292

VIP: variable important for the projection; FC: fold change; DG: diacylglycerol; MG: monoacylglycerol; CL: cardiolipin; FA: fatty acid; LPC: lysophosphatidylcholine; PC: phosphatidylcholine; LPE: lysophosphatidylethanolamine; PE: phosphatidylethanolamine; LPI: lysophosphatidylinositol; PS: phosphatidylserine; PG: phosphatidylglycerol; LPG: lysophosphatidylglycerol; SM: sphingomyelin.