Effect of Interaction between Early Menarche and Genetic Polymorphisms on Triglyceride

Table 2

Association of age at menarche with metabolic traits (data are expressed as beta coefficients, with 95% confidence intervals, for linear regression adjusted for age, area, education, income, and CRP level) in KARE.

Metabolic traits	Age at menarche (years)						^a
	≤12	13	14	15	16	≥17
	Beta coefficient (95% CI)
SBP (mmHg)	2.22 (−1.65–6.10)	−1.51 (−3.82–0.80)	1.17 (−0.64–2.99)	0.54 (−1.11–2.18)	0 (−1.66–1.66)	−0.004 (−1.53–1.52)	0.27
DBP (mmHg)	1.26 (−0.98–3.50)	−0.34 (−1.71–1.03)	0.44 (−0.63–1.51)	0.42 (−0.56–1.39)	0 (−0.96–0.96)	0.58 (−0.32–1.49)	0.44
FI (mg/dl)	−0.02 (−0.92–0.88)	0.07 (−0.51–0.65)	−0.002 (−0.47–0.46)	−0.24 (−0.64–0.17)	0 (−0.40–0.40)	−0.40 (−0.77–0.03)	0.91
FG (μU/ml)	2.19 (−1.13–5.51)	−0.50 (−2.42–1.42)	0.71 (−0.94–2.37)	0.63 (−0.94–2.19)	0 (−1.44–1.44)	0.97 (−0.58–2.5)	0.12
WC (cm)	3.54 (1.53–5.55)	0.79 (−0.42–2.00)	0.55 (−0.40–1.49)	0.26 (−0.63–1.15)	0 (−0.86–0.86)	−0.52 (−1.33–0.29)	<0.01
TG (mg/dl)	37.83 (16.00–59.66)	4.67 (−6.93–16.26)	3.15 (−6.60–12.90)	1.80 (−6.29–9.90)	0 (−8.24–8.24)	−0.004 (−7.81–7.80)	0.02
HDL (mg/dl)	−0.07 (−2.48–2.33)	0.52 (−0.94–1.99)	0.81 (−0.38–2.00)	0.11 (−0.95–1.17)	0 (−1.03–1.03)	0.66 (−0.31–1.64)	0.71

SBP: systolic blood pressure; DBP: diastolic blood pressure; FI: fasting insulin; FG: fasting glucose; WC: waist circumference; TG: triglyceride; HDL: high-density lipoprotein. ^aAge at menarche as a dummy variable (≤12 years: 0, >12 years: 1), .