Curculigoside Protects against Excess-Iron-Induced Bone Loss by Attenuating Akt-FoxO1-Dependent Oxidative Damage to Mice and Osteoblastic MC3T3-E1 Cells

Table 1

Effects of CUR on femoral BMD, architecture, and mechanical properties in iron-overload mice.

	Control	Iron treatment	NAC (500 mg/kg)	CUR (25 mg/kg)	CUR (50 mg/kg)	CUR (100 mg/kg)
Micro-CT
BMD (Au/mm^3)			^##			^##
BS/BV (%)			^##			^#
BVF (%)			^##			^#
Trabecular bone
Trabecular number (N/mm)			^##			^#
Trabecular spacing (μm)			^##			^#
Trabecular thickness (μm)			^##			^#
Cortical bone
Cortical thickness (mm)			^##			^##
Cortical area (mm^2)			^##			^#
Marrow area (mm^2)			^##			^##
Mechanical properties
Elastic load (N)						^##
Elastic stress (N/mm^2)			^#
Elastic modulus (Gpa)		0.84 ± 0.20	^#			^#
Maximum load (N)
Maximum stress (N/mm^2)			^#			^#

Results are represented as the (). , compared to the control group; ^#, ^##, compared to the iron-treated group.