Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer

<div>Downregulation of Trx-1 by lentiviral vector-mediated RNAi inhibits gastric cancer cell growth, clone formation, invasion and migration. (a) Decreased Trx-1 mRNA level in BGC-823 cells transduced with lenti-shTrx-1 revealed by quantitative RT-PCR. (b) Decreased Trx-1 protein level in BGC-823 cell transduced with lenti-shTrx-1 revealed by Western blotting. (c) Downregulation of Trx-1 inhibited BGC-823 cell growth as revealed by CCK-8 assay. (d) Downregulation of Trx-1 inhibited BGC-823 cell plate colony formation. (e) Downregulation of Trx-1 inhibited BGC-823 cell migration and invasion. Representative images from triplicate experiments are shown. Magnification, ×200. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer 