Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer

<div>Trx-1 promotes gastric cancer cell growth, migration, and invasion through activation of AKT signaling. (a) Overexpression of Trx-1 increased phosphorylated AKT (p-AKT) and decreased PTEN expression levels in AGS cells. (b) Knockdown of Trx-1 expression decreased p-AKT and increased PTEN expression levels in BGC-823 cells. (c, d) Inhibition of AKT signaling pathway inhibited cell growth in AGS and BGC-823 cells. Cells were treated with AKT inhibitor MK2206 (1, 5, and 10 <i>μ</i>M) for 24 and 48 hours; CCK-8 assays were performed. (e, f) Inhibition of AKT signaling pathway inhibited AGS and BGC-823 cell migration and invasion. Representative images from triplicate experiments are shown. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer 