Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer

Table 2

Cox regression analysis of Trx-1 protein expression and clinicopathological covariates.

Characteristics	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Trx-1-high vs.Trx-1-low	5.56 (2.88–10.75)	<0.001	5.44 (2.73–10.75)	<0.001
Age (≥65 vs. <65)	1.44 (0.85–2.41)	0.174	1.26 (0.73–2.17)	0.414
Sex (male vs. female)	1.64 (0.97–2.76)	0.066	1.03 (0.60–1.76)	0.932
Clinical stage (III vs. I–II)	3.30 (1.92–5.67)	<0.001	1.77 (0.81–3.86)	0.152
Higher differentiation grade	1.91 (1.10–3.29)	0.021	2.58 (1.46–4.56)	0.001
Advanced tumor stage	3.59 (1.90–6.78)	<0.001	1.61 (0.67–3.91)	0.290
Tumor size (≥3.4 vs. <3.4)	3.21 (1.78–5.78)	<0.001	1.70 (0.89–3.25)	0.108

HR: hazard ratio; CI: confidence interval. , which was considered statistically significant.