[Retracted] Hydrostatin-SN10 Ameliorates Pancreatitis-Induced Lung Injury by Affecting IL-6-Induced JAK2/STAT3-Associated Inflammation and Oxidative Stress

Figure 10

Schematic diagram of the effects of hydrostatin-SN10 on the JAK2/STAT3 signaling pathway. Hydrostatin-SN10 exerts its anti-inflammation and antioxidant properties via IL-6-induced JAK/STAT3 signaling pathway. IL-6 binds to the IL-6 receptor on the cell membrane. The complex of IL-6 and IL-6R interacts the JAK2 and activates transcription factors of the signal transducers and activators of STAT3 and initiates JAK2/STAT2 signaling. STAT3 is phosphorylated and then forms dimers with other STAT. The activated STAT3 complex will then enter into the nucleus initiating or inhibiting transcription of its regulating genes (including inflammatory cytokines, oxidative stress, and apoptosis factors), resulting in the changes of cell apoptosis.