Melatonin against Myocardial Ischemia-Reperfusion Injury: A Meta-analysis and Mechanism Insight from Animal Studies

Table 5

Post hoc subgroup analysis of pooled estimates of infarct size.

Pooled estimates	No. of studies	WMD	95% CI	value	Heterogeneity
Species
Rats	10	-19.06	-23.87, -14.25	<0.001	,
Mice	5	-24.83	-39.20, -10.46	<0.001	,
Study type
In vivo	11	-21.27	-28.50, -14.04	<0.001	,
Ex vivo	4	-18.76	-26.22, -11.29	<0.001	,
Reperfusion duration
≥6 h	11	-22.84	-28.89, -16.78	<0.001	,
<6 h	4	-13.04	-16.40, -9.68	<0.001	,
Timing regimen of pretreatment
>60 min	6	-24.89	-33.87, -15.92	<0.001	,
≤60 min	9	-17.68	-23.45, -11.92	<0.001	,
Overall	15	-20.45	-25.43, -15.47	<0.001	,