Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice

Figure 1

Antidiabetic effects of MFE on alloxan-induced diabetic mice. Mice were administered with MFE (0, 100, and 200 mg/kg orally) or glibenclamide (5 mg/kg orally) once a day for 12 weeks after an alloxan challenge (50 mg/kg). Body weight, blood glucose levels, and water and food intake were monitored once per week during the experimental period. In the oral glucose tolerance test, fasted mice were administered with a glucose solution (1 g/kg orally) before they were sacrificed. Data are expressed as the . and versus the alloxan-treated group. (a) Body weight. (b) Food intake. (c) Water intake. (d) Blood glucose. (e) Oral glucose tolerance.

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