Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway

<div>Cancer stem-like sphere cells differentiate to endothelial cells. Cells were cultured in MCDB131 endothelial medium with or without VEGF (10 ng/ml) for two generations. Expressions of endothelial markers CD31 (a) and vWF (b) were detected with immunofluorescence staining. The cell nuclei were counterstained with DAPI (200 ×). (c) Formation of capillary-like structure on Matrigel (100×). (d) A number of formed tubes were calculated. 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Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway 

Figure 2 | Reactive Oxygen Species Induce Endothelial Differentiation of Liver Cancer Stem-Like Sphere Cells through the Activation of Akt/IKK Signaling Pathway 