Lipin1 Is Involved in the Pathogenesis of Diabetic Encephalopathy through the PKD/Limk/Cofilin Signaling Pathway

Figure 3

Results of behavioral tests in rats in response to LV injection. (a) Illustration of the viral infusion of LV-Lipin1. (b) The Lipin1 content in the CA1 region after LV injection as determined with use of qPCR and Western blot analysis. (c) Open field test. The number of squares crossed indicates general locomotor activity while time in central area indicates the amount of exploration. (d) Novel object recognition test. The total exploration time and discrimination index were analyzed. (e) Morris water maze test. The escape latencies on different training days and the number of platform crossings were determined. Movements of the rats were also recorded using tracking software. Data represent the , animals per group. , , versus WT+LV-Con group; ^#, ^## versus DE+LV-Con group. .

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