Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis

Figure 1

KL administration improves the survival rate and attenuates PQ-induced lung injury in the ALI mouse model. (a) Kaplan-Meier survival curve of rats receiving different treatments. KL administration improved the survival rate of rats receiving PQ treatment. The contents of the proinflammatory cytokines IL-1β (b) and IL-6 (c) in the BALF were measured by ELISA. (d) The lung W/D ratio was calculated to assess lung edema in different treatment groups. (e) H&E staining of lung tissue sections from each group of mice. This figure showed KL administration attenuated pathological damage after PQ application. (f) The lung injury scores for the lung tissue of different treatment groups. (g) Effects of KL administration on PQ- induced apoptosis of lung cells. Apoptosis in situ was measured using TUNEL assay. Data are shown as the . versus control group; ^## versus PQ group, ANOVA.

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