Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis

<div>KL reduces intracellular ROS, lowers MDA, and improves GSH contents in PQ-exposed A549 cells. (a) The intracellular ROS production in A549 cells receiving different treatments was detected by the DCFH-DA method immediately after laser irradiation using a fluorescence microscope. (b) The ROS level of each sample was determined via DCF fluorescence intensity. The fluorescence intensity was calculated by Image-Pro Plus 6.0. The contents of MDA (c) and GSH (d) were measured by colorimetry as described in Materials and Methods. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis 