HSF1 Attenuates LPS-Induced Acute Lung Injury in Mice by Suppressing Macrophage Infiltration

Figure 3

HSF1 attenuates the MCP-1 expression in serum, lung tissue, and BALF from LPS-induced ALI mice. MCP-1 levels were measured in (a) serum, (b) lung tissue, and (c) BALF at 12 h, 24 h, and 36 h after LPS treatment. (d) MCP-1 mRNA levels in the lung tissue from LPS-induced ALI mice using qRT-PCR. (e) HSF1 mRNA levels in the lung tissue from LPS-induced ALI mice using qRT-PCR. ^#, ^##, versus HSF1^+/++NS group; , , versus HSF1^+/++LPS group; mice per group. values were determined using two-tailed Student’s -test for comparing two groups and one-way ANOVA for comparing multiple groups.

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