The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance

<div>MAVS knockdown is resistant to radiation response. (a) The comparison of MAVS expression among A549, BEAS-2B, HepG2, and MCF7 cells. The expressions of MAVS at the indicated time points after 2 Gy X-rays in negative vector or MAVS-silenced A549 cells (b) and BEAS-2B cells (c) by western blot assay. Survival in A549 cells (d) and BEAS-2B cells (e) transfected with siRNA-MAVS or negative vector and then exposed to 0, 1, 2, 4, or 6 Gy X-rays measured by colony formation assay. (f) The fraction analysis of MN in negative vector and MAVS silenced in A549 and BEAS-2B cells after 2 Gy X-ray irradiation. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance 