Posttranslational Modification Defects in Fibroblast Growth Factor Receptor 1 as a Reason for Normosmic Isolated Hypogonadotropic Hypogonadism

Figure 5

A relevance between GnRH-deficiency-related signaling network and several known disease-causing genes of olfactory dysfunction by using STRING software. The protein-protein interaction network encoded by pathogenic genes known to cause KS including FGFR1 (colored blue) were correlated with CEP290-related protein-protein network involving olfactory dysfunction via several pathways containing the factors of FGF8, NTRK2, AHI1, and IFT88.