Norepinephrine Induces Lung Microvascular Endothelial Cell Death by NADPH Oxidase-Dependent Activation of Caspase-3

Figure 3

NE increases Nox2 and Nox4 mRNA expression. Rat lung microvascular endothelial cells (RLMEC) were stimulated with norepinephrine (NE, 5 ng/mL) or vehicle (V) for 4 to 24 hours (h). (a) NE does not alter mRNA expression of Nox1. (b) NE increases mRNA expression of Nox2 after 24 hours. (c) NE increased mRNA expression of Nox4 in a time-dependent manner. vs. vehicle (V). /group.

(a)

(b)

(c)