IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

Figure 5

IKKε deficiency diminished a ROS production and VSMC loss. (a) Representative in situ DHE staining of aortas from Apoe^−/− versus Apoe^−/−IKKε^−/− mice infused with saline or Ang II for 28 days. , respectively, Quantification shown in the right panels. (b) TUNEL staining. (c) cleaved caspase-3 staining in aortic sections at 28 days post infusion. , respectively. Quantification shown in the right panels. (d) α-SMA staining of aneurysmal aortic sections from mice. , respectively. Quantification shown in the right panels. vs. Apoe^−/−IKKε^−/− mice, vs. Apoe^−/−IKKε^−/− mice.

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