IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

Figure 7

IKKε inhibitor amlexanox treatment reduces Ang II-induced AAA formation in Apoe^−/− mice. (a) AAA incidence and Kaplan-Meier survival curve following 4 weeks of Ang II infusion treated with water or amlexanox in Apoe^−/−mice. mice per group. (b) MMP expression and activity in Apoe^−/− mice following 4 weeks of Ang II infusion treated with water or amlexanox, , respectively. (c) Macrophage infiltration in Apoe^−/− mice following 4 weeks of Ang II infusion treated with water or amlexanox, , respectively. (d) TNFα, MCP1, and IL6 expression in aortic tissue samples detected by ELISA, , respectively. vs. amlexanox treatment mice. (e) Analysis of treated with water or amlexanox control on ROS production, , respectively. Quantification shown in the right panels. (f) Total and phosphorylated protein levels of ERK1/2 in Apoe^−/− mice following 4 weeks of Ang II infusion treated with water or amlexanox, , respectively. Quantification shown in the right panels. vs. amlexanox treatment mice.

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