Research Article
The Calcilytic Drug Calhex-231 Ameliorates Vascular Hyporesponsiveness in Traumatic Hemorrhagic Shock by Inhibiting Oxidative Stress and miR-208a-Mediated Mitochondrial Fission
Figure 2
Effect of Calhex-231 on survival and hemodynamic parameters in rats with THS: (a, b) Kaplan-Meier survival curve and survival time (); (c–f) hemodynamics, including mean arterial pressure (MAP), left intraventricular systolic pressure (LVSP), and maximal change rate in left intraventricular pressure (±dp/dtmax) (). compared with the sham-operated group; #, ## compared with the LR group. Sham: sham-operated; LR: lactated Ringer’s solution; Cal: Calhex-231; B: baseline; S: shock.
| (a) |
| (b) |
| (c) |
| (d) |
| (e) |
| (f) |