The Calcilytic Drug Calhex-231 Ameliorates Vascular Hyporesponsiveness in Traumatic Hemorrhagic Shock by Inhibiting Oxidative Stress and miR-208a-Mediated Mitochondrial Fission

Figure 6

Effect of Calhex-231 on oxidative stress in vivo and in vitro: (a–d) levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) in blood samples (); (e) images acquired by confocal microscopy showing intracellular ROS levels in VSMCs; (f) quantitative data of the mean intensity of 2,7-dichlorofluorescin (DCF, a probe of ROS) fluorescence (). , compared with the sham-operated group; #, ## compared with the LR group; @@ compared with the normal group; ^^ compared with the hypoxia group. Sham: sham-operated; LR: lactated Ringer’s solution; Cal: Calhex-231; Norm: normal; Hyp: hypoxia.

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