Interplay between Nox2 Activity and Platelet Activation in Patients with Sepsis and Septic Shock: A Prospective Study

Table 1

Clinical characteristics of all patients and comparison between patients with sepsis and those with septic shock.

Variables	Healthy controls; ()	Overall; ()	Patients with sepsis; ()	Patients with septic shock; ()
Demographics
Male	5 (50%)	16 (48.5%)	9 (45%)	7 (53.8%)	0.619
Age, median (IQR)	68.5 (62-73)	75 (54-85)	74 (54-82.5)	79 (52.5-86.5)	0.888
Previous hospitalization, last 3 months	—	14 (42.4%)	7 (35%)	7 (53.8%)	0.284
Previous antibiotic therapy, last 30 days	—	7 (21.1%)	6 (30%)	1 (7.7%)	0.126
Comorbidities
Cardiovascular disease	—	19 (57.6%)	11 (55%)	8 (61.5%)	0.710
Chronic heart failure	—	9 (27.3%)	4 (20%)	5 (38.5%)	0.245
Diabetes	—	7 (21.1%)	5 (25%)	2 (15.4%)	0.509
Chronic kidney disease	—	15 (45.5%)	7 (30%)	8 (61.5%)	0.073
Hepatic disease	—	4 (12.1%)	1 (5%)	3 (23.1%)	0.120
Neurologic disease	—	8 (24.2%)	5 (25%)	3 (23.1%)	0.9
COPD	—	9 (27.3%)	6 (20%)	3 (23.1%)	0.833
Solid cancer	—	7 (21.1%)	5 (25%)	2 (15.4%)	0.509
Splenectomy	—	1 (3%)	0	1 (7.7%)	0.208
Aspirin use	—	10 (30.3%)	7 (35%)	3 (23.1%)	0.466
Charlson Comorbidity Index	—		4.5 (1-7)	8 (2-9)	0.298
Source of infection
Respiratory tract	—	9 (27.3%)	6 (30%)	3 (23.1%)	0.663
Genitourinary tract	—	8 (24.2%)	4 (20%)	4 (30.8%)	0.481
Abdomen	—	8 (24.2%)	4 (20%)	4 (30.8%)	0.481
Skin and soft tissue	—	1 (3%)	1 (5%)	0	0.413
Meningitis	—	1 (3%)	1 (5%)	0	0.413
Bone	—	1 (3%)	1 (5%)	0	0.413
Intravascular device	—	1 (3%)	0	1 (7.7%)	0.208
Others	—	4 (12.1%)	3 (15%)	1 (7.7%)	0.530
PICC	—	3 (9.1%)	2 (10%)	1 (7.7%)	0.822
CVC	—	2 (6.1%)	1 (5%)	1 (7.7%)	0.751
NIV	—	4 (12.1%)	2 (10%)	2 (15.4%)	0.643
Severity scores of sepsis
SAPS-II	—	34 (23.5-42)	32 (17.5-38)	37 (31-51)	0.024
qSOFA	—	2 (1-2)	1 (0-2)	2 (2-2.5)	0.002
SOFA score	—	6 (4-10)	4.5 (2-6)	10 (7.5-12)	<0.001
Use of inotropes	—	9 (27.3%)	—	9 (69.2%)	<0.001
Mortality	—	9 (27.3%)	3 (15%)	6 (46.2%)	0.050

COPD = chronic obstructive pulmonary disease; CVC = central venous catheter; IQR: interquartile range; NIV = noninvasive ventilation; PICC = peripheral inserted central catheter. Others include 1 malaria (sepsis), 1 mononucleosis (sepsis), and 2 bacteremia with an unknown source of infection (1 sepsis and 1 septic shock).