The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer

Figure 1

Proteasome inhibition can enhance the sensitivity of A2780 cells to cisplatin compared with SKOV3 cells. (a) A2780 and SKOV3 cells were treated with different concentrations of Epox for 24 h, and cell viability was determined using the MTT assay. Data are presented as the , , , compared with the respective controls. (b) A2780 and SKOV3 cells were treated with 100 nM Epox and different concentrations of cisplatin for 24 h, and cell viability was determined using the MTT assay. Data are presented as the (), , compared with the respective control, ^# compared with the cisplatin-treated groups.

(a)

(b)