Research Article

Cardioprotective Natural Compound Pinocembrin Attenuates Acute Ischemic Myocardial Injury via Enhancing Glycolysis

Figure 7

Knockdown of PFKFB3 in the myocardium using AAV9 impairs pinocembrin-induced cardioprotection after MI/R. (a) Representative infarct staining from AAV-shNC or AAV-shPFKFB3 mice treated with vehicle or pinocembrin. (b, c) AAR and infarct sizes from AAV-shNC or AAV-shPFKFB3 mice treated with vehicle or pinocembrin. (d, e) Plasma LDH activity and cTnI levels. (f) Representative echocardiographic images, assessment of LV EF and FS by echocardiography from AAV-shNC or AAV-shPFKFB3 mice treated with vehicle or pinocembrin. each. Data represent the . , significantly different as indicated.
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