Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury

<div>Pyruvate/IOX2 could attenuate injury induced by OGD/R in SH-SY5Y cells. (a) The result of CCK-8 showed 1000 <i>μ</i>M of pyruvate was cytotoxic in comparison to others. (b) The result of CCK-8 showed 500 <i>μ</i>M of IOX2 was cytotoxic in comparison to others. (c) Both pyruvate and IOX2 play a protective role of SH-SY5Y treated by OGD/R according to the result of CCK-8. (e–h) Flow cytometry displays the apoptosis rate is increased in the OGD/R group, while downregulated by pyruvate/IOX2, and summarized data of flow cytometry was exhibited (d). 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury 

Figure 7 | Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury 