Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury

<div>Reperfusion could reverse the increase expression of autophagy-related genes (a–d) and the HIF-1<i>α</i> signal pathway (e–h) in mRNA level in SH-SY5Y cells compared with the OGD group, while pyruvate could reverse the decline of the HIF-1<i>α</i> pathway and autophagy-related mRNA expression during reperfusion. 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Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury 

Figure 9 | Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury 