The Activation of Phosphatidylserine/CD36/TGF-β1 Pathway prior to Surgical Brain Injury Attenuates Neuroinflammation in Rats

Figure 4

PS liposome or isoflurane pretreatment effects on neuroinflammation within peri-resection region of brain at 24 h post-SBI. Representative Western blot bands (a). Quantitative analysis of Western blot bands showed that PS liposome pretreatment increased TGF-β1 level (b) and decreased proinflammatory cytokines level of IL-1β and TNFα (c, d). Isoflurane pretreatment resulted in significant decreases in IL-1β and TNFα (c, d) with tendency toward increase in TGF-β1 level (b). . , vs. sham; ^&&, ^& vs. SBI+vehicle.

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