Functional Redox Proteomics Reveal That <i>Salvia miltiorrhiza</i> Aqueous Extract Alleviates Adriamycin-Induced Cardiomyopathy via Inhibiting ROS-Dependent Apoptosis

<div>(a) Upper panels: histologic examination of heart tissue by Masson’s trichrome staining and immunohistochemical analysis for control group, ADR-treated group, and ADR+SMAE group. The positive signals showing blue color demonstrated an accumulation of collagen and were zoomed in by white squares (indicated by black arrows; original magnification: ×200). Lower panels: the regions with differently expressed caspase-3 were indicated by red arrows. Original magnification: ×400. (b) Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) experiment was performed with immunohistochemical examination of rat heart, and the red arrows indicated TUNEL-positive signals. The quantification of the TUNEL-positive cardiomyocytes per cm<sup>2</sup> in various treatments was shown by bar chart. 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Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: Functional Redox Proteomics Reveal That <i>Salvia miltiorrhiza</i> Aqueous Extract Alleviates Adriamycin-Induced Cardiomyopathy via Inhibiting ROS-Dependent Apoptosis 

Figure 1 | Functional Redox Proteomics Reveal That Salvia miltiorrhiza Aqueous Extract Alleviates Adriamycin-Induced Cardiomyopathy via Inhibiting ROS-Dependent Apoptosis 